The seconds, who recorded their second victory in succession following a ten try bonanza at the Memorial Ground, were quickly into their stride after Scott Manning had burst through for an unconverted try in the fourth minute.
Two minutes later Adam Macluskie celebrated his return from injury with a well worked try following a looping run around the defenders, Neil Walker added the conversion.
In the tenth minute a fired up Adam Macluskie powerfully carved his way over. Scrum half Taylor Mills, who constantly probed and nagged at the home side's defence, touched down following one of his sniping runs in the shadow of a solid scrum.
Vale's composure and dominance was momentarily shattered when they failed to close down a Wilmslow attack that resulted in an unconverted try.
Normal service was resumed by the man of the moment, Adam Macluskie, when he surged through the defensive cover to collect a deserved hat trick.
The second half began with the Vale firmly in the pilot's seat. Prop Joe Stevens bustled his way over, his try being efficiently converted by Jamie Antcliffe who had worked on his kicking technique since his last outing.
He also converted his side's next try which had all the hallmarks of being out of the top drawer. From the left hand side Neil Walker boomed a kick crossfield into the waiting arms of Dan Helme on the right flank for a five pointer that had the Vale players and supporters purring with delight.
Taylor Mills, not for the first time caught Wilmslow napping, with a ground hugging dart for his brace converted by Jamie Antcliffe in the fifty fifth minute.
Hooker Richard Hodgson, continued his run of fine form at the coal face with a try, converted by Jamie Antcliffe. Harry Fellows completed the try scoring in what had been a most rewarding Cheshire experience for the whole Vale squad.
Winger forward Sam Hoare worked hard to put his name on the score sheet, lock Sam Hadlington produced another rock steady contribution which ensured line out dominance but it was a day to remember for Adam Macluskie.
Vale will be hoping their upsurge in form will stand them in good stead when the host seventh in the league Chester 2 on Saturday, fully aware that they defeated them at home in the final game of last season, but of course every season is different.